Cygene Standard Testing Policies

Conventional DNA tests, based solely on target amplification technology, are limited to evaluating small sample sizes per test, a practice which leads to potential false negatives. This genetic testing process is like searching only a small amount of hay to find the proverbial "needle in the haystack."

In that sense, CyGene's Haystack ProcessingTM dna analysis methodology can be compared with searching the entire haystack for the needle. Using proprietary or conventional target isolation technologies, combined with signal amplification post-target isolation detection methods, Haystack genetic testing Processing can locate the presence of "extremely rare targets." This method further reduces false negative results.

CyGene's Haystack Processing technology, coupled with AGENDATM, the Company's proprietary robotic platform for genomic analysis, allows life sciences to evolve from the research lab to the commercial marketplace.

CyGene's proprietary Haystack Processing methods have several benefits:

• They offer the ability to test a large sample size, increasing sensitivity
• The target capture methods increase specificity of results, reducing false positive results
• They allow the detection of disease-causing entities at the earliest point in the infection time-course for pro-active results
• They facilitate the monitoring of the patient during therapeutic treatment, allowing for drug modulation based on the patient's response to the drug
• The development of fully automated methods for Haystack Processing will lead to the use of these technologies in point-of-care applications (such as hospitals, doctors and veterinary offices, and water treatment plantsworldwide)
• After the initial diagnosis, Haystack Processing allows for the monitoring of the therapeutic process by helping to determine the anticipated reduction in viral or other disease load in the patient. CyGene's pharmacogenomic genetic profiling provides customized information about what drugs to use and which ones will be metabolized best.